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Target
Polyphenol oxidase 2
Ligand
BDBM50241213
Substrate
n/a
Meas. Tech.
ChEMBL_520697 (CHEMBL966086)
IC50
2700±n/a nM
Citation
 Liu, J; Cao, R; Yi, W; Ma, C; Wan, Y; Zhou, B; Ma, L; Song, H A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds. Eur J Med Chem 44:1773-8 (2009) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
White button mushroom
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50241213
Synonyms:
(Z)-1-((E)-3-phenylallylidene)thiosemicarbazide | 1-(3-Phenylallylidene)thiosemicarbazide | CHEMBL388025
Type:
Small organic molecule
Emp. Form.:
C10H11N3S
Mol. Mass.:
205.279
SMILES:
NC(=S)NN=CC=Cc1ccccc1 |w:4.3,6.5|
Structure:
Search PDB for entries with ligand similarity: