Reaction Details Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM50262843
Substrate
n/a
Meas. Tech.
ChEMBL_489268 (CHEMBL990824)
IC50
>1600±n/a nM
Citation
 Oslund, RC; Cermak, N; Gelb, MH Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2. J Med Chem 51:4708-14 (2008) [PubMed]  Article 
Target
Name:
Phospholipase A2
Synonyms:
Group IB phospholipase A2 | PA21B_HUMAN | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2 (PLA2) | Phospholipase A2 group 1B | phospholipase A2 precursor
Type:
Protein
Mol. Mass.:
16364.13
Organism:
Homo sapiens (Human)
Description:
P04054
Residue:
148
Sequence:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
  
Inhibitor
Name:
BDBM50262843
Synonyms:
Benzenesulfonyl-2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-isobutyl-1H-indol-4-yloxy)acetamide | CHEMBL479251
Type:
Small organic molecule
Emp. Form.:
C29H29N3O6S
Mol. Mass.:
547.622
SMILES:
CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3)cccc2n1Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: