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Target
Glutamate racemase
Ligand
BDBM50263141
Substrate
n/a
Meas. Tech.
ChEMBL_490179 (CHEMBL983838)
IC50
4300±n/a nM
Citation
 Geng, B; Breault, G; Comita-Prevoir, J; Petrichko, R; Eyermann, C; Lundqvist, T; Doig, P; Gorseth, E; Noonan, B Exploring 9-benzyl purines as inhibitors of glutamate racemase (MurI) in Gram-positive bacteria. Bioorg Med Chem Lett 18:4368-72 (2008) [PubMed]  Article 
Target
Name:
Glutamate racemase
Synonyms:
MURI_ENTFA | murI
Type:
PROTEIN
Mol. Mass.:
29478.43
Organism:
Enterococcus faecalis (strain ATCC 700802 / V583)
Description:
ChEMBL_558148
Residue:
273
Sequence:
MSNQEAIGLIDSGVGGLTVLKEALKQLPNERLIYLGDTARCPYGPRPAEQVVQFTWEMADFLLKKRIKMLVIACNTATAVALEEIKAALPIPVVGVILPGARAAVKVTKNNKIGVIGTLGTIKSASYEIAIKSKAPTIEVTSLDCPKFVPIVESNQYRSSVAKKIVAETLQALQLKGLDTLILGCTHYPLLRPVIQNVMGSHVTLIDSGAETVGEVSMLLDYFDIAHTPEAPTQPHEFYTTGSAKMFEEIASSWLGIENLKAQQIHLGGNEND
  
Inhibitor
Name:
BDBM50263141
Synonyms:
9-(2,6-difluoro-3-methylbenzyl)-2-(1,1,1,2,2-pentafluoropentan-3-yloxy)-9H-purin-6-amine | CHEMBL476994
Type:
Small organic molecule
Emp. Form.:
C18H16F7N5O
Mol. Mass.:
451.3414
SMILES:
CCC(Oc1nc(N)c2ncn(Cc3c(F)ccc(C)c3F)c2n1)C(F)(F)C(F)(F)F
Structure:
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