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Target
Beta-1 adrenergic receptor
Ligand
BDBM50236187
Substrate
n/a
Meas. Tech.
ChEMBL_535275 (CHEMBL981734)
EC50
>100±n/a nM
Citation
 Nakajima, Y; Imanishi, M; Itou, S; Hamashima, H; Tomishima, Y; Washizuka, K; Sakurai, M; Matsui, S; Imamura, E; Ueshima, K; Yamamoto, T; Yamamoto, N; Ishikawa, H; Nakano, K; Unami, N; Hamada, K; Hattori, K Discovery of novel series of benzoic acid derivatives containing biphenyl ether moiety as potent and selective human beta(3)-adrenergic receptor agonists: Part IV. Bioorg Med Chem Lett 18:5037-40 (2008) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51338.40
Organism:
Homo sapiens (Human)
Description:
P08588
Residue:
477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
  
Inhibitor
Name:
BDBM50236187
Synonyms:
(R)-3-(4-(2-(2-(3-chlorophenyl)-2-hydroxyethylamino)ethyl)phenoxy)benzoic acid | 3-[4-(2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-ethyl)phenoxy]benzoic acid | CHEMBL409828
Type:
Small organic molecule
Emp. Form.:
C23H22ClNO4
Mol. Mass.:
411.878
SMILES:
O[C@@H](CNCCc1ccc(Oc2cccc(c2)C(O)=O)cc1)c1cccc(Cl)c1 |r|
Structure:
Search PDB for entries with ligand similarity: