Reaction Details Report a problem with these data
Target
Alpha-2C adrenergic receptor
Ligand
BDBM50311076
Substrate
n/a
Meas. Tech.
ChEMBL_619545 (CHEMBL1111402)
Ki
>10000±n/a nM
Citation
 Donohue, SR; Varnäs, K; Jia, Z; Gulyás, B; Pike, VW; Halldin, C Synthesis and in vitro autoradiographic evaluation of a novel high-affinity radioiodinated ligand for imaging brain cannabinoid subtype-1 receptors. Bioorg Med Chem Lett 19:6209-12 (2009) [PubMed]  Article 
Target
Name:
Alpha-2C adrenergic receptor
Synonyms:
ADA2C_HUMAN | ADRA2C | ADRA2L2 | ADRA2RL2 | Adrenergic alpha2C | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2C-, receptor | Alpha-2 adrenergic receptor subtype C4 | Alpha-2C adrenoceptor | Alpha-2C adrenoreceptor | adrenergic, alpha-2C-, receptor [Homo sapiens]
Type:
Enzyme
Mol. Mass.:
49552.32
Organism:
Homo sapiens (Human)
Description:
P18825
Residue:
462
Sequence:
MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
  
Inhibitor
Name:
BDBM50311076
Synonyms:
CHEMBL1079079 | [125I]1-(2-iodophenyl)-4-cyano-5-(4-methoxyphenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C23H22IN5O2
Mol. Mass.:
527.3576
SMILES:
COc1ccc(cc1)-c1c(C#N)c(nn1-c1ccccc1I)C(=O)NN1CCCCC1
Structure:
Search PDB for entries with ligand similarity: