Reaction Details Report a problem with these data
Target
Deoxycytidine kinase
Ligand
BDBM50311598
Substrate
n/a
Meas. Tech.
ChEMBL_618630 (CHEMBL1101518)
IC50
15300±n/a nM
Citation
Jessop, TC; Tarver, JE; Carlsen, M; Xu, A; Healy, JP; Heim-Riether, A; Fu, Q; Taylor, JA; Augeri, DJ; Shen, M; Stouch, TR; Swanson, RV; Tari, LW; Hunter, M; Hoffman, I; Keyes, PE; Yu, XC; Miranda, M; Liu, Q; Swaffield, JC; David Kimball, S; Nouraldeen, A; Wilson, AG; Foushee, AM; Jhaver, K; Finch, R; Anderson, S; Oravecz, T; Carson, KG Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors. Bioorg Med Chem Lett 19:6784-7 (2009) [PubMed] Article
More Info.:
Target
Name:
Deoxycytidine kinase
Synonyms:
DCK | DCK_HUMAN
Type:
PROTEIN
Mol. Mass.:
30510.65
Organism:
Human
Description:
ChEMBL_1437135
Residue:
260
Sequence:
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL
Inhibitor
Name:
BDBM50311598
Synonyms:
3'-(N-((1S,3S)-3-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)cyclopentyl)sulfamoyl)biphenyl-4-carboxylic acid | CHEMBL1079758
Type:
Small organic molecule
Emp. Form.:
C22H21FN4O5S
Mol. Mass.:
472.489
SMILES:
Nc1nc(=O)n(cc1F)[C@H]1CC[C@@H](C1)NS(=O)(=O)c1cccc(c1)-c1ccc(cc1)C(O)=O |r|