Reaction Details Report a problem with these data
Target
Cytochrome P450 11B1, mitochondrial
Ligand
BDBM50047262
Substrate
n/a
Meas. Tech.
ChEMBL_643965 (CHEMBL1211864)
IC50
9.9±n/a nM
Citation
Adams, CM; Hu, CW; Jeng, AY; Karki, R; Ksander, G; Lasala, D; Leung-Chu, J; Liang, G; Liu, Q; Meredith, E; Rao, C; Rigel, DF; Shi, J; Smith, S; Springer, C; Zhang, C The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-beta-hydroxylase. Bioorg Med Chem Lett 20:4324-7 (2010) [PubMed] Article
More Info.:
Target
Name:
Cytochrome P450 11B1, mitochondrial
Synonyms:
C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH
Type:
Enzyme
Mol. Mass.:
57591.44
Organism:
Homo sapiens (Human)
Description:
P15538
Residue:
503
Sequence:
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN
Inhibitor
Name:
BDBM50047262
Synonyms:
(R)-4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile | 4-(5,6,7,8-Tetrahydro-imidazo[1,5-a]pyridin-5-yl)-benzonitrile | CHEMBL287677 | R-fadrozole
Type:
Small organic molecule
Emp. Form.:
C14H13N3
Mol. Mass.:
223.2731
SMILES:
N#Cc1ccc(cc1)[C@H]1CCCc2cncn12