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Target
NADPH oxidase 4
Ligand
BDBM50065271
Substrate
n/a
Meas. Tech.
ChEMBL_658093 (CHEMBL1249158)
IC50
630±n/a nM
Citation
 Borbély, G; Szabadkai, I; Horváth, Z; Markó, P; Varga, Z; Breza, N; Baska, F; Vántus, T; Huszár, M; Geiszt, M; Hunyady, L; Buday, L; Orfi, L; Kéri, G Small-molecule inhibitors of NADPH oxidase 4. J Med Chem 53:6758-62 (2010) [PubMed]  Article 
Target
Name:
NADPH oxidase 4
Synonyms:
KOX-1 | Kidney oxidase-1 | Kidney superoxide-producing NADPH oxidase | NOX4 | NOX4_HUMAN | RENOX | Renal NAD(P)H-oxidase
Type:
PROTEIN
Mol. Mass.:
66954.54
Organism:
Human
Description:
ChEMBL_792879
Residue:
578
Sequence:
MAVSWRSWLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRASASVLNLNCSLILLPMCRTLLAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHVAAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTYAIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLPEYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLYRYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLHNKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGKTVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
  
Inhibitor
Name:
BDBM50065271
Synonyms:
3-(4-hydroxy-3,5-diisopropylbenzylidene)indolin-2-one | 3-[1-(4-Hydroxy-3,5-diisopropyl-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one | CHEMBL85021 | ST-280
Type:
Small organic molecule
Emp. Form.:
C21H23NO2
Mol. Mass.:
321.4128
SMILES:
CC(C)c1cc(\C=C2/C(=O)Nc3ccccc23)cc(C(C)C)c1O
Structure:
Search PDB for entries with ligand similarity: