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Target
Chymase
Ligand
BDBM50332960
Substrate
n/a
Meas. Tech.
ChEMBL_696202 (CHEMBL1639355)
IC50
3.1±n/a nM
Citation
 Mehta, PD; Sengar, NP; Pathak, AK 2-Azetidinone--a new profile of various pharmacological activities. Eur J Med Chem 45:5541-60 (2010) [PubMed]  Article 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM50332960
Synonyms:
(3S,4S)-4-(4-Carboxy)phenoxy-1-[diphenylmethyl)aminocarbonyl]-3-(2-ethoxybenzyl)azetidin-2-one | CHEMBL1631756
Type:
Small organic molecule
Emp. Form.:
C33H30N2O6
Mol. Mass.:
550.6011
SMILES:
CCOc1ccccc1C[C@H]1[C@@H](Oc2ccc(cc2)C(O)=O)N(C(=O)NC(c2ccccc2)c2ccccc2)C1=O |r|
Structure:
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