Reaction Details Report a problem with these data
Target
Phosphomannomutase 2
Ligand
BDBM44451
Substrate
n/a
Meas. Tech.
ChEMBL_747526 (CHEMBL1777060)
IC50
>20000±n/a nM
Citation
Dahl, R; Bravo, Y; Sharma, V; Ichikawa, M; Dhanya, RP; Hedrick, M; Brown, B; Rascon, J; Vicchiarelli, M; Mangravita-Novo, A; Yang, L; Stonich, D; Su, Y; Smith, LH; Sergienko, E; Freeze, HH; Cosford, ND Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia. J Med Chem 54:3661-8 (2011) [PubMed] Article
More Info.:
Target
Name:
Phosphomannomutase 2
Synonyms:
PMM2 | PMM2_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28082.33
Organism:
Homo sapiens (Human)
Description:
gi_4557839
Residue:
246
Sequence:
MAAPGPALCLFDVDGTLTAPRQKITKEMDDFLQKLRQKIKIGVVGGSDFEKVQEQLGNDVVEKYDYVFPENGLVAYKDGKLLCRQNIQSHLGEALIQDLINYCLSYIAKIKLPKKRGTFIEFRNGMLNVSPIGRSCSQEERIEFYELDKKENIRQKFVADLRKEFAGKGLTFSIGGQISFDVFPDGWDKRYCLRHVENDGYKTIYFFGDKTMPGGNDHEIFTDPRTMGYSVTAPEDTRRICELLFS
Inhibitor
Name:
BDBM44451
Synonyms:
MLS000043622 | N-(2-oxidanylidene-1,3-benzoxathiol-5-yl)-N-(phenylsulfonyl)ethanamide | N-(2-oxo-1,3-benzoxathiol-5-yl)-N-(phenylsulfonyl)acetamide | N-(benzenesulfonyl)-N-(2-oxo-1,3-benzoxathiol-5-yl)acetamide | N-besyl-N-(2-keto-1,3-benzoxathiol-5-yl)acetamide | SMR000020638 | cid_3244786
Type:
Small organic molecule
Emp. Form.:
C15H11NO5S2
Mol. Mass.:
349.382
SMILES:
CC(=O)N(c1ccc2oc(=O)sc2c1)S(=O)(=O)c1ccccc1