Reaction Details Report a problem with these data
Target
Proton-coupled folate transporter
Ligand
BDBM50354833
Substrate
n/a
Meas. Tech.
ChEMBL_771183 (CHEMBL1837100)
pH
6.8±n/a
Ki
1820±n/a nM
Comments
extracted
Citation
Wang, L; Desmoulin, SK; Cherian, C; Polin, L; White, K; Kushner, J; Fulterer, A; Chang, MH; Mitchell-Ryan, S; Stout, M; Romero, MF; Hou, Z; Matherly, LH; Gangjee, A Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits b-glycinamide ribonucleotide formyltransferase. J Med Chem 54:7150-64 (2011) [PubMed] Article
More Info.:
Target
Name:
Proton-coupled folate transporter
Synonyms:
G21 | HCP1 | Heme carrier protein 1 | PCFT | PCFT/HCP1 | PCFT_HUMAN | SLC46A1 | Solute carrier family 46 member 1
Type:
PROTEIN
Mol. Mass.:
49782.13
Organism:
Human
Description:
ChEMBL_1469597
Residue:
459
Sequence:
MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGTRQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKSTRLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNFMKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP