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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM50355972
Substrate
n/a
Meas. Tech.
ChEMBL_776056 (CHEMBL1912526)
IC50
15000±n/a nM
Citation
 Nishiguchi, GA; Atallah, G; Bellamacina, C; Burger, MT; Ding, Y; Feucht, PH; Garcia, PD; Han, W; Klivansky, L; Lindvall, M Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases. Bioorg Med Chem Lett 21:6366-9 (2011) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM50355972
Synonyms:
CHEMBL1910902
Type:
Small organic molecule
Emp. Form.:
C23H22N4
Mol. Mass.:
354.4476
SMILES:
C1CN(CCN1)c1ccc(cc1)-c1c[nH]c2ccc(cc12)-c1cccnc1
Structure:
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