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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50283375
Substrate
n/a
Meas. Tech.
ChEBML_62470
Ki
99500±n/a nM
Citation
 Stoelwinder, J; Roberti, M; Kozikowski, AP; Johnson, KM; Bergmann, JS Differential binding and dopamine uptake activity of cocaine analogues modified at nitrogen Bioorg Med Chem Lett 4:303-308 (1994)    Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50283375
Synonyms:
3-Benzoyloxy-8-nitroso-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | CHEMBL102325
Type:
Small organic molecule
Emp. Form.:
C16H18N2O5
Mol. Mass.:
318.3245
SMILES:
COC(=O)C1C2CCC(CC1OC(=O)c1ccccc1)N2N=O |TLB:21:20:4.10.9:6.7,THB:11:10:20:6.7,2:4:20:6.7|
Structure:
Search PDB for entries with ligand similarity: