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Target
Neprilysin
Ligand
BDBM50286917
Substrate
n/a
Meas. Tech.
ChEBML_140877
IC50
366±n/a nM
Citation
 Kanno, H; Osanai, K; Furugohri, T; Watanabe, Y Potent inhibitors of neutral endopeptidase. 2-Biphenyl- methylglutaric acid amide derivatives Bioorg Med Chem Lett 6:65-70 (1996)    Article 
Target
Name:
Neprilysin
Synonyms:
Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11
Type:
Protein
Mol. Mass.:
85789.59
Organism:
Rat
Description:
P07861
Residue:
750
Sequence:
MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKDVLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGTSWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERIGYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW
  
Inhibitor
Name:
BDBM50286917
Synonyms:
(R)-2-[(R)-2-(Carboxymethyl-carbamoyl)-3-(4-pyrazol-1-yl-phenyl)-propyl]-hexanoic acid | CHEMBL159884
Type:
Small organic molecule
Emp. Form.:
C21H27N3O5
Mol. Mass.:
401.4562
SMILES:
CCCC[C@H](C[C@H](Cc1ccc(cc1)-n1cccn1)C(=O)NCC(O)=O)C(O)=O
Structure:
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