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Target
Integrase
Ligand
BDBM50421534
Substrate
n/a
Meas. Tech.
ChEMBL_90577 (CHEMBL701161)
IC50
19000±n/a nM
Citation
 Guenther, S; Nair, V Binding modes of two novel dinucleotide inhibitors of HIV-1 integrase. Bioorg Med Chem Lett 12:2233-6 (2002) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50421534
Synonyms:
CHEMBL2309960
Type:
Small organic molecule
Emp. Form.:
C19H26N8O12P2
Mol. Mass.:
620.4037
SMILES:
Nc1ccn([C@H]2C[C@@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](COP(O)(O)=O)OC[C@@H]3n3cnc4c(N)ncnc34)O2)c(=O)n1 |r|
Structure:
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