Reaction Details Report a problem with these data
Target
Carbonic anhydrase 4
Ligand
BDBM10874
Substrate
n/a
Meas. Tech.
ChEBML_45423
Ki
17±n/a nM
Citation
 Vullo, D; Franchi, M; Gallori, E; Pastorek, J; Scozzafava, A; Pastorekova, S; Supuran, CT Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides. Bioorg Med Chem Lett 13:1005-9 (2003) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 4
Synonyms:
CA-IV | CA4 | CAH4_BOVIN | Carbonate dehydratase IV | Carbonic Anhydrase IV | Carbonic anhydrase | Carbonic anhydrase 4
Type:
Enzyme
Mol. Mass.:
35152.74
Organism:
Bos taurus (bovine)
Description:
Bovine isozyme, isolated from lung microsomes
Residue:
312
Sequence:
MRLLLALLVLAAAPPQARAASHWCYQIQVKPSNYTCLEPDEWEGSCQNNRQSPVNIVTAKTQLDPNLGRFSFSGYNMKHQWVVQNNGHTVMVLLENKPSIAGGGLSTRYQATQLHLHWSRAMDRGSEHSFDGERFAMEMHIVHEKEKGLSGNASQNQFAEDEIAVLAFMVEDGSKNVNFQPLVEALSDIPRPNMNTTMKEGVSLFDLLPEEESLRHYFRYLGSLTTPTCDEKVVWTVFQKPIQLHRDQILAFSQKLFYDDQQKVNMTDNVRPVQSLGQRQVFRSGAPGLLLAQPLPTLLAPVLACLTVGFLR
  
Inhibitor
Name:
BDBM10874
Synonyms:
6-hydroxy-1,3-benzothiazole-2-sulfonamide | CHEMBL6685 | aromatic/heteroaromatic sulfonamide 19
Type:
Small organic molecule
Emp. Form.:
C7H6N2O3S2
Mol. Mass.:
230.264
SMILES:
NS(=O)(=O)c1nc2ccc(O)cc2s1
Structure:
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