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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50140101
Substrate
n/a
Meas. Tech.
ChEMBL_71445 (CHEMBL685317)
Ki
87±n/a nM
Citation
 Guo, Z; Zhu, YF; Gross, TD; Tucci, FC; Gao, Y; Moorjani, M; Connors, PJ; Rowbottom, MW; Chen, Y; Struthers, RS; Xie, Q; Saunders, J; Reinhart, G; Chen, TK; Bonneville, AL; Chen, C Synthesis and structure-activity relationships of 1-arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonists. J Med Chem 47:1259-71 (2004) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50140101
Synonyms:
3-[2-((S)-Cyclobutylamino)-propyl]-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione; hydrochloride | CHEMBL553990
Type:
Small organic molecule
Emp. Form.:
C26H28F3N3O3
Mol. Mass.:
487.514
SMILES:
COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(CC(C)NC2CCC2)c1=O |(-.51,5.44,;.83,4.67,;.83,3.13,;-.51,2.35,;-.51,.8,;.83,.04,;2.16,.81,;2.16,2.35,;3.51,3.13,;3.49,.04,;3.49,-1.52,;2.16,-2.29,;4.84,-2.29,;4.85,-3.83,;6.18,-4.61,;6.18,-6.15,;4.85,-6.92,;7.51,-6.91,;8.85,-6.13,;8.85,-4.59,;7.51,-3.82,;8.93,-3.02,;6.17,-1.5,;7.51,-2.28,;6.16,.04,;7.49,.82,;8.84,.05,;10.17,.83,;10.11,-1.22,;11.44,-.43,;12.21,-1.76,;13.55,-.99,;12.77,.35,;4.82,.81,;4.82,2.35,)|
Structure:
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