Reaction Details Report a problem with these data
Target
Somatostatin receptor type 1
Ligand
BDBM50165177
Substrate
n/a
Meas. Tech.
ChEMBL_306862 (CHEMBL827597)
IC50
>1000±n/a nM
Citation
 Schottelius, M; Reubi, JC; Eltschinger, V; Schwaiger, M; Wester, HJ N-terminal sugar conjugation and C-terminal Thr-for-Thr(ol) exchange in radioiodinated Tyr3-octreotide: effect on cellular ligand trafficking in vitro and tumor accumulation in vivo. J Med Chem 48:2778-89 (2005) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 1
Synonyms:
SOMATOSTATIN SST1 | SRIF-2 | SS-1-R | SS1-R | SS1R | SSR1_HUMAN | SSTR1 | Somatostatin receptor type 1 (SSTR1)
Type:
Enzyme
Mol. Mass.:
42692.81
Organism:
Homo sapiens (Human)
Description:
P30872
Residue:
391
Sequence:
MFPNGTASSPSSSPSPSPGSCGEGGGSRGPGAGAADGMEEPGRNASQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCTSRITTL
  
Inhibitor
Name:
BDBM50165177
Synonyms:
4-[(4R,7S,10S,13R,16S)-4-{[(2R)-1,3-dihydroxybutan-2-yl]carbamoyl}-16-[(4-hydroxy-3-iodophenyl)methyl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-19-[3-phenyl-2-({[(4R)-2,3,4,5-tetrahydroxyoxan-2-yl]methyl}azaniumyl)propanamido]-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-10-yl]butan-1-aminium | Radiolabeled octreotide derivative
Type:
Small organic molecule
Emp. Form.:
C55H77IN10O16S2
Mol. Mass.:
1325.291
SMILES:
CC(O)[C@@H](CO)NC(=O)[C@@H]1CSSCC(NC(=O)C(Cc2ccccc2)[NH2+]CC2(O)OCC(O)[C@@H](O)C2O)C(=O)N[C@@H](Cc2ccc(O)c(I)c2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCC[NH3+])C(=O)N[C@@H](C(C)O)C(=O)N1
Structure:
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