Reaction Details Report a problem with these data
Target
Lanosterol 14-alpha demethylase
Ligand
BDBM50213698
Substrate
n/a
Meas. Tech.
ChEMBL_459077 (CHEMBL925157)
IC50
55000±n/a nM
Citation
 Jain, KS; Kathiravan, MK; Somani, RS; Shishoo, CJ The biology and chemistry of hyperlipidemia. Bioorg Med Chem 15:4674-99 (2007) [PubMed]  Article 
Target
Name:
Lanosterol 14-alpha demethylase
Synonyms:
CP51A_RAT | CYPLI | Cyp51 | Cyp51a1 | Cytochrome P450 51 | Cytochrome P450 51A1 | LDM | Lanosterol 14-alpha demethylase | P450-14DM | P45014DM | P450LI | Sterol 14-alpha demethylase
Type:
PROTEIN
Mol. Mass.:
56717.47
Organism:
Rattus norvegicus
Description:
ChEMBL_52075
Residue:
503
Sequence:
MVLLGLLQSGGSVLGQAMEQVTGGNLLSTLLIACAFTLSLVYLFRLAVGHMVQLPAGAKSPPYIYSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEEVYGRLTTPVFGKGVAYDVPNAVFLEQKKILKSGLNIAHFKQYVSIIEKEAKEYFKSWGESGERNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKNIFYKAIQKRRLSKEPAEDILQTLLDSTYKDGRPLTDDEIAGMLIGLLLAGQHTSSTTSAWMGFFLARDKPLQDKCYLEQKTVCGEDLPPLTYEQLKDLNLLDRCIKETLRLRPPIMTMMRMAKTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLINGYFPSVNYTTMIHTPENPVIRYKRRSK
  
Inhibitor
Name:
BDBM50213698
Synonyms:
(1R,3aS,3bR,5aS,7S,9aS,9bS,11aR,E)-3,10-dihydroxy-5,13,14-trimethyl-17-((R)-6-methylheptan-2-yl)-dodecahydro-2H-cyclopenta[a]phenanthren-15(9H,14H,16H)-one oxime | CHEMBL255059
Type:
Small organic molecule
Emp. Form.:
C28H49NO3
Mol. Mass.:
447.6936
SMILES:
CC(C)CCC[C@@H](C)[C@H]1CC(N=O)[C@@]2(C)[C@@H]3CC[C@@]4(C)C[C@@H](O)CC[C@]4(O)[C@H]3CC[C@]12C
Structure:
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