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Target
Melanocortin receptor 4
Ligand
BDBM50308328
Substrate
n/a
Meas. Tech.
ChEMBL_613851 (CHEMBL1067674)
EC50
31623±n/a nM
Citation
 Szewczyk, JR; Laudeman, CP; Sammond, DM; Villeneuve, M; Minick, DJ; Grizzle, MK; Daniels, AJ; Andrews, JL; Ignar, DM A concise synthesis of 1,4-dihydro-[1,4]diazepine-5,7-dione, a novel 7-TM receptor ligand core structure with melanocortin receptor agonist activity. Bioorg Med Chem 18:1822-33 (2010) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50308328
Synonyms:
(+/-)-Phenyl hydrogen{[6-(1H-indazol-3-ylmethyl)-5,7-dioxo-4-phenyl-4,5,6,7-tetrahydro-1H-1,4-diazepin-1-yl]methyl}phosphonate | CHEMBL598208
Type:
Small organic molecule
Emp. Form.:
C28H25N4O6P
Mol. Mass.:
544.4951
SMILES:
OP(=O)(CC(=O)CN1C=CN(c2ccccc2)C(=O)C(Cc2n[nH]c3ccccc23)C1=O)Oc1ccccc1 |c:8|
Structure:
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