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Target
Translocator protein
Ligand
BDBM22041
Substrate
n/a
Meas. Tech.
ChEMBL_829916 (CHEMBL2061564)
Ki
0.5±n/a nM
Citation
 Castellano, S; Taliani, S; Milite, C; Pugliesi, I; Da Pozzo, E; Rizzetto, E; Bendinelli, S; Costa, B; Cosconati, S; Greco, G; Novellino, E; Sbardella, G; Stefancich, G; Martini, C; Da Settimo, F Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein. J Med Chem 55:4506-10 (2012) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM22041
Synonyms:
2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]-N,N-dipropylacetamide | Alpidem | Ananxyl | CHEMBL54349 | S-800342
Type:
Small organic molecule
Emp. Form.:
C21H23Cl2N3O
Mol. Mass.:
404.333
SMILES:
CCCN(CCC)C(=O)Cc1c(nc2ccc(Cl)cn12)-c1ccc(Cl)cc1
Structure:
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