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Target
Cathepsin S
Ligand
BDBM50392211
Substrate
n/a
Meas. Tech.
ChEMBL_852706 (CHEMBL2156828)
Ki
61±n/a nM
Citation
 Frizler, M; Schmitz, J; Schulz-Fincke, AC; Gütschow, M Selective nitrile inhibitors to modulate the proteolytic synergism of cathepsins S and F. J Med Chem 55:5982-6 (2012) [PubMed]  Article 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Human
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM50392211
Synonyms:
CHEMBL2153164
Type:
Small organic molecule
Emp. Form.:
C20H23N3O4S2
Mol. Mass.:
433.544
SMILES:
CC(C)CS(=O)(=O)CC(NC(=O)c1ccc(s1)-c1ccccc1)C(=O)NCC#N
Structure:
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