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Target
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Ligand
BDBM50399411
Substrate
n/a
Meas. Tech.
ChEMBL_877886 (CHEMBL2188143)
IC50
8±n/a nM
Citation
 Gerusz, V; Denis, A; Faivre, F; Bonvin, Y; Oxoby, M; Briet, S; LeFralliec, G; Oliveira, C; Desroy, N; Raymond, C; Peltier, L; Moreau, F; Escaich, S; Vongsouthi, V; Floquet, S; Drocourt, E; Walton, A; Prouvensier, L; Saccomani, M; Durant, L; Genevard, JM; Sam-Sambo, V; Soulama-Mouze, C From triclosan toward the clinic: discovery of nonbiocidal, potent FabI inhibitors for the treatment of resistant bacteria. J Med Chem 55:9914-28 (2012) [PubMed]  Article 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Synonyms:
Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI | FABI_STAAR | NADPH-dependent enoyl-ACP reductase | fabI | trans-2-enoyl-[acyl carrier protein] reductase
Type:
Enzyme
Mol. Mass.:
27989.00
Organism:
Staphylococcus aureus
Description:
Q6GI75
Residue:
256
Sequence:
MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK
  
Inhibitor
Name:
BDBM50399411
Synonyms:
CHEMBL2178304 | PT405
Type:
Small organic molecule
Emp. Form.:
C14H12F2O2
Mol. Mass.:
250.2407
SMILES:
CCc1cc(O)c(Oc2ccccc2F)cc1F
Structure:
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