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Target
Phospholipase A2, membrane associated
Ligand
BDBM50428494
Substrate
n/a
Meas. Tech.
ChEMBL_943475 (CHEMBL2342415)
IC50
241000±n/a nM
Citation
 Ye, L; Dickerson, T; Kaur, H; Takada, YK; Fujita, M; Liu, R; Knapp, JM; Lam, KS; Schore, NE; Kurth, MJ; Takada, Y Identification of inhibitors against interaction between pro-inflammatory sPLA2-IIA protein and integrinavß3. Bioorg Med Chem Lett 23:340-5 (2012) [PubMed]  Article 
Target
Name:
Phospholipase A2, membrane associated
Synonyms:
GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A
Type:
Hydrolase
Mol. Mass.:
16101.20
Organism:
Homo sapiens (Human)
Description:
The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:
144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
  
Inhibitor
Name:
BDBM50428494
Synonyms:
CHEMBL2335195
Type:
Small organic molecule
Emp. Form.:
C17H15N5O4S
Mol. Mass.:
385.397
SMILES:
Cc1nc(NC(=O)c2ccccc2)sc1-c1cc([nH]n1)C(=O)NCC(O)=O
Structure:
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