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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50442802
Substrate
n/a
Meas. Tech.
ChEMBL_989970 (CHEMBL2447327)
IC50
>100000±n/a nM
Citation
 Dickens, MP; Roxburgh, P; Hock, A; Mezna, M; Kellam, B; Vousden, KH; Fischer, PM 5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2. Bioorg Med Chem 21:6868-77 (2013) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM50442802
Synonyms:
CHEMBL2443388
Type:
Small organic molecule
Emp. Form.:
C17H9ClFN3O2
Mol. Mass.:
341.724
SMILES:
Fc1ccccc1-n1c2ccc(Cl)cc2cc2c1nc(=O)[nH]c2=O |(27.54,-55.69,;28.87,-56.46,;28.87,-58,;30.21,-58.77,;31.55,-57.99,;31.54,-56.46,;30.2,-55.69,;30.2,-54.15,;31.53,-53.38,;32.87,-54.14,;34.2,-53.37,;34.2,-51.82,;35.52,-51.04,;32.86,-51.06,;31.53,-51.83,;30.2,-51.07,;28.87,-51.84,;28.87,-53.38,;27.53,-54.15,;26.19,-53.39,;24.86,-54.16,;26.19,-51.83,;27.53,-51.06,;27.54,-49.52,)|
Structure:
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