Reaction Details Report a problem with these data
Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50006621
Substrate
n/a
Meas. Tech.
ChEMBL_1335296 (CHEMBL3238720)
Ki
0.930000±n/a nM
Citation
 Gao, Y; Kellar, KJ; Yasuda, RP; Tran, T; Xiao, Y; Dannals, RF; Horti, AG Derivatives of dibenzothiophene for positron emission tomography imaging ofa7-nicotinic acetylcholine receptors. J Med Chem 56:7574-89 (2013) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rattus norvegicus (Rat)
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50006621
Synonyms:
CHEMBL3235487
Type:
Small organic molecule
Emp. Form.:
C19H19IN2O2S
Mol. Mass.:
466.336
SMILES:
Ic1cccc2-c3ccc(cc3S(=O)(=O)c12)N1CCN2CCC1CC2 |(29.41,-16.94,;30.31,-18.18,;29.68,-19.6,;30.58,-20.84,;32.11,-20.67,;32.75,-19.26,;34.21,-18.78,;35.54,-19.56,;36.88,-18.79,;36.88,-17.24,;35.54,-16.47,;34.21,-17.24,;32.75,-16.77,;33.07,-15.26,;31.6,-15.74,;31.84,-18.02,;38.22,-16.47,;39.42,-17.43,;40.92,-17.09,;41.58,-15.71,;40.92,-14.31,;39.42,-13.97,;38.22,-14.92,;39.51,-14.95,;40.15,-16.52,)|
Structure:
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