Reaction Details Report a problem with these data
Target
Histone deacetylase 2
Ligand
BDBM50055518
Substrate
n/a
Meas. Tech.
ChEMBL_1452234 (CHEMBL3366146)
IC50
6.3±n/a nM
Citation
 Kim, B; Park, H; Salvador, LA; Serrano, PE; Kwan, JC; Zeller, SL; Chen, QY; Ryu, S; Liu, Y; Byeon, S; Luesch, H; Hong, J Evaluation of class I HDAC isoform selectivity of largazole analogues. Bioorg Med Chem Lett 24:3728-31 (2014) [PubMed]  Article 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM50055518
Synonyms:
CHEMBL3317815
Type:
Small organic molecule
Emp. Form.:
C21H29N5O4S3
Mol. Mass.:
511.681
SMILES:
C[C@@]12CSC(=N1)c1csc(CNC(=O)C[C@H](OC(=O)[C@H](CCCN)NC2=O)\C=C\CCS)n1 |r,c:4|
Structure:
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