Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50193439
Substrate
n/a
Meas. Tech.
ChEMBL_1615946 (CHEMBL3858015)
Ki
385±n/a nM
Citation
 Zampieri, D; Vio, L; Fermeglia, M; Pricl, S; Wünsch, B; Schepmann, D; Romano, M; Mamolo, MG; Laurini, E Computer-assisted design, synthesis, binding and cytotoxicity assessments of new 1-(4-(aryl(methyl)amino)butyl)-heterocyclic sigma 1 ligands. Eur J Med Chem 121:712-726 (2016) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Guinea pig
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50193439
Synonyms:
CHEMBL3894565
Type:
Small organic molecule
Emp. Form.:
C20H21ClN2O2
Mol. Mass.:
356.846
SMILES:
CN(CCCCN1C(=O)C(=O)c2ccccc12)Cc1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: