Reaction Details Report a problem with these data
Target
Major prion protein
Ligand
BDBM54422
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
5712±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM54422
Synonyms:
4-(4-bromophenyl)-2-[(3,4,5-trimethoxybenzoyl)amino]-3-thenoic acid | 4-(4-bromophenyl)-2-[(3,4,5-trimethoxybenzoyl)amino]thiophene-3-carboxylic acid | 4-(4-bromophenyl)-2-[(3,4,5-trimethoxyphenyl)carbonylamino]thiophene-3-carboxylic acid | 4-(4-bromophenyl)-2-[[oxo-(3,4,5-trimethoxyphenyl)methyl]amino]-3-thiophenecarboxylic acid | MLS001164606 | SMR000539809 | US20230364057, Compound 189 | cid_1332923
Type:
Small organic molecule
Emp. Form.:
C21H18BrNO6S
Mol. Mass.:
492.34
SMILES:
COc1cc(cc(OC)c1OC)C(=O)Nc1scc(c1C(O)=O)-c1ccc(Br)cc1
Structure:
Search PDB for entries with ligand similarity: