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Target
Oxysterols receptor LXR-beta
Ligand
BDBM49636
Substrate
n/a
Meas. Tech.
Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based screening assay to identify agonists of the Liver-X-Receptor (LXR).
IC50
67533±n/a nM
Citation
 PubChem, PC Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based screening assay to identify agonists of the Liver-X-Receptor (LXR). PubChem Bioassay (2013)[AID] 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM49636
Synonyms:
(E)-1-(2,3-dihydroindol-1-yl)-3-thiophen-2-yl-2-propen-1-one | (E)-1-(2,3-dihydroindol-1-yl)-3-thiophen-2-yl-prop-2-en-1-one | (E)-1-(2,3-dihydroindol-1-yl)-3-thiophen-2-ylprop-2-en-1-one | (E)-1-indolin-1-yl-3-(2-thienyl)prop-2-en-1-one | 1-[3-(2-thienyl)acryloyl]indoline | MLS000678854 | SMR000269910 | cid_885474
Type:
Small organic molecule
Emp. Form.:
C15H13NOS
Mol. Mass.:
255.335
SMILES:
O=C(\C=C\c1cccs1)N1CCc2ccccc12
Structure:
Search PDB for entries with ligand similarity: