Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM116210
Substrate
n/a
Meas. Tech.
κ-Opioid Receptor Binding Assays
pH
7.4±n/a
Temperature
277.15±n/a K
Ki
4232±n/a nM
Comments
extracted
Citation
 Brown, KC; Goehring, RR 2,3,4,5-tetrahydro-benzo{B}{1,4}diazepine-comprising compounds of formula(III) for treating pain US Patent  US8637502 Publication Date 1/28/2014 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Human
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM116210
Synonyms:
US8637502, 44
Type:
Small organic molecule
Emp. Form.:
C23H30N4O2
Mol. Mass.:
394.5099
SMILES:
O=c1n(CC#N)c2ccccc2n(C2CCN(CC2)C2CCCCCCC2)c1=O
Structure:
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