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Target
Lysosomal Pro-X carboxypeptidase
Ligand
BDBM155346
Substrate
n/a
Meas. Tech.
Enzyme Activity Assay
pH
5.5±n/a
IC50
554±n/a nM
Comments
extracted
Citation
 Debenham, JS; Jiang, J; Madsen-Duggan, CB; Shen, D Prolylcarboxypeptidase inhibitors US Patent  US9006268 Publication Date 4/14/2015 
Target
Name:
Lysosomal Pro-X carboxypeptidase
Synonyms:
Angiotensinase C | Lysosomal carboxypeptidase C | PCP | PCP_HUMAN | PRCP | Proline carboxypeptidase | Prolylcarboxypeptidase | Prolylcarboxypeptidase (PRCP)
Type:
Enzyme
Mol. Mass.:
55805.19
Organism:
Homo sapiens (Human)
Description:
P42785
Residue:
496
Sequence:
MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH
  
Inhibitor
Name:
BDBM155346
Synonyms:
US9006268, 9
Type:
Small organic molecule
Emp. Form.:
C27H26N4O
Mol. Mass.:
422.5215
SMILES:
CC(=O)N1C[C@@H](CC[C@H]1c1ccccc1)c1[nH]c(nc1-c1ccccn1)-c1ccccc1 |r|
Structure:
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