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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM168933
Substrate
n/a
Meas. Tech.
Homogeneous Time Resolved Fluorescence Assay
Ki
12±n/a nM
Citation
 Bacani, GM; Eccles, W; Fitzgerald, AE; Goldberg, SD; Hack, MD; Hawryluk, NA; Jones, WM; Keith, JM; Krawczuk, P; Lebsack, AD; Lee-Dutra, A; Liu, J; McClure, KJ; Meduna, SP; Pippel, DJ; Rosen, MD; Sales, ZS Flap modulators US Patent  US9079866 Publication Date 7/14/2015 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM168933
Synonyms:
US9079866, 334 | US9745328, Compound 334 | US9884878, Compound 334
Type:
Small organic molecule
Emp. Form.:
C20H15FN6S
Mol. Mass.:
390.437
SMILES:
Nc1cc(Sc2ccccc2-c2ccc(c(F)c2)-c2cnc(N)nc2)ncn1
Structure:
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