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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM184624
Substrate
n/a
Meas. Tech.
Radioligand Binding
pH
7.4±n/a
Temperature
277.15±n/a K
IC50
400±n/a nM
EC50
63±n/a nM
Comments
extracted
Citation
 Donde, Y; Nguyen, JH; Kedzie, KM; Gil, DW; Donello, JE; Im, W Treatment of inflammatory bowel disease US Patent  US9156810 Publication Date 10/13/2015 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM184624
Synonyms:
US9156810, 43
Type:
Small organic molecule
Emp. Form.:
C22H34O5
Mol. Mass.:
378.5024
SMILES:
CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C(C)(C)C(=O)[C@@H]1CC#CCCCC(O)=O
Structure:
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