Reaction Details Report a problem with these data
Target
Genome polyprotein [2420-3010,S282T]
Ligand
BDBM240844
Substrate
n/a
Meas. Tech.
HCV Replicon Assay
pH
7.5±n/a
Temperature
300.15±n/a K
IC50
>100000±n/a nM
Comments
extracted
Citation
 Du, J; Sofia, MJ 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections US Patent  US9394331 Publication Date 7/19/2016 
Target
Name:
Genome polyprotein [2420-3010,S282T]
Synonyms:
POLG_HCVCO | RNA-directed RNA polymerase (NS5B) (S282T)
Type:
Enzyme
Mol. Mass.:
65797.38
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
S282T
Residue:
591
Sequence:
SMSYTWTGALITPCAAEETKLPINALSNSLLRHHNLVYATTSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSARSKFGYGAKDVRNLSSKAVNHIRSVWKDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPGQRVEFLVNAWKAKKCPMGFAYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRATGVLTTSCGNTLTCYLKAAAACRAAKLQDCTMLVCGDDLVVICESAGTQEDEASLRAFTEAMTRYSAPPGDPPKPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIQRLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVRTKLKLTPIPAASQLDLSSWFVAGYSGGDIYHSLSRARPRWFMWCLLLLSVGVGIYLLPNR
  
Inhibitor
Name:
BDBM240844
Synonyms:
US9394331, 136 | US9394331, 48
Type:
Small organic molecule
Emp. Form.:
C11H14N2O6
Mol. Mass.:
270.2387
SMILES:
OCC1OC(n2ccc(=O)[nH]c2=O)[C@@]2(CCO2)[C@@H]1O |r|
Structure:
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