Reaction Details Report a problem with these data
Target
Cathepsin S
Ligand
BDBM248157
Substrate
n/a
Meas. Tech.
Cathepsin Activity Assay
pH
6.5±0
Temperature
298.15±0 K
IC50
3.1±0.4 nM
Citation
 Tsai, JY; Lee, MJ; Chang, MD; Wang, HC; Lin, CC; Huang, H Effects of novel human cathepsin S inhibitors on cell migration in human cancer cells. J Enzyme Inhib Med Chem 29:538-46 (2014) [PubMed]  Article 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM248157
Synonyms:
Cathepsin S inhibitor alpha-ketoamide, 6e
Type:
Small organic molecule
Emp. Form.:
C32H40N4O10
Mol. Mass.:
640.6808
SMILES:
CCOC(=O)CNC(=O)C(=O)C(COCc1ccccc1)NC(=O)C(CC1CCCCC1)NC(=O)c1cc(OC)ccc1[N+]([O-])=O |w:11.11|
Structure:
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