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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM228294
Substrate
n/a
Meas. Tech.
Kinase Inhibition Assay
IC50
8.00±n/a nM
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, MD; Ho, K Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors US Patent  US10392392 Publication Date 8/27/2019 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM228294
Synonyms:
US10047093, 8-11 | US10392392, Example 8-11 | US10875864, EX. 8-11
Type:
Small organic molecule
Emp. Form.:
C20H21F3N4O2
Mol. Mass.:
406.4015
SMILES:
OC[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1 |r,wU:2.1,wD:5.8,(-7.96,5.19,;-7.96,3.65,;-6.62,2.88,;-5.24,3.62,;-3.91,2.85,;-3.91,1.31,;-5.24,.54,;-6.57,1.31,;-2.57,.54,;-1.24,1.31,;-1.24,2.85,;.09,3.62,;1.43,2.85,;2.89,3.33,;3.8,2.08,;2.89,.84,;3.29,-.65,;2.2,-1.74,;2.6,-3.23,;4.09,-3.62,;5.23,-2.55,;6.72,-2.95,;7.81,-1.86,;8.9,-.77,;8.9,-2.95,;6.72,-.77,;4.78,-1.05,;1.43,1.31,;.09,.54,)|
Structure:
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