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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM377145
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
>20001±n/a nM
Citation
 Xue, C; Li, Y; Feng, H; Zhang, K Thiazolecarboxamides and pyridinecarboxamide compounds useful as PIM kinase inhibitors US Patent  US10517858 Publication Date 12/31/2019 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM377145
Synonyms:
N-{4-[(3S)-3-Aminopiperidin-1-yl]quinolin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide | US10265307, Example 2 | US10517858, Example 2 | US10828290, Example 2 | US11229631, Example 2
Type:
Small organic molecule
Emp. Form.:
C24H21F2N5OS
Mol. Mass.:
465.518
SMILES:
N[C@H]1CCCN(C1)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnc2ccccc12 |r|
Structure:
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