Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM453275
Substrate
n/a
Meas. Tech.
Inhibition of Lysine Gingipain
IC50
4680±n/a nM
Citation
 Konradi, AW; Galemmo, Jr., RA; Dominy, SS; Lynch, CC; Holsinger, LJ Ketone inhibitors of lysine gingipain US Patent  US10730826 Publication Date 8/4/2020 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM453275
Synonyms:
BDBM453327 | US10730826, Compound 1a-non-racemic | US10730826, Compound 1a-racemic | US11325884, Compound 1
Type:
Small organic molecule
Emp. Form.:
C19H25F3N2O3
Mol. Mass.:
386.4086
SMILES:
NCCCC[C@H](NC(=O)C1CCCC1)C(=O)COc1c(F)ccc(F)c1F |r|
Structure:
Search PDB for entries with ligand similarity: