Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM474221
Substrate
n/a
Meas. Tech.
FLIPR and cAMP Inhibition Assay
IC50
10.00±n/a nM
Citation
 Zeng, Q; Qi, C; Tsui, H; Yang, Z; Zhang, X Triazolo-pyrimidine compounds and uses thereof US Patent  US10858365 Publication Date 12/8/2020 
Target
Name:
Adenosine receptor A2a
Synonyms:
AA2AR_MOUSE | Adenosine A2a receptor | Adenosine receptor A2a | Adora2a
Type:
PROTEIN
Mol. Mass.:
44984.04
Organism:
Mouse
Description:
ChEMBL_479903
Residue:
410
Sequence:
MGSSVYIMVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGMRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDENSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCQHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFRAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSAPHSGRRPNGYTLGPGGGGSTQGSPGDVELLTQEHQEGQEHPGLGDHLAQGRVGTASWSSEFAPS
  
Inhibitor
Name:
BDBM474221
Synonyms:
8-(2,6-dimethylpyridin-4-yl)-7-(4-fluoropheny1)- 2-[(3-fluoropyridin-2-yl)methyl]-[l,2,4]triazolo [1,5-c]pyrimidin-5-amine | US10858365, Compound 1 | US11629147, Cmpd. 1
Type:
Small organic molecule
Emp. Form.:
C23H17F2N7O
Mol. Mass.:
445.4242
SMILES:
Cn1cc(ccc1=O)-c1c(nc(N)n2nc(Cc3ncccc3F)nc12)-c1ccc(F)cc1
Structure:
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