Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM507030
Substrate
n/a
Meas. Tech.
Receptor Binding Assays
Ki
1058±n/a nM
Citation
 Martin, SF; Sahn, JJ; Hodges, TR Piperazinyl norbenzomorphan compounds and methods for using the same US Patent  US11046670 Publication Date 6/29/2021 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM507030
Synonyms:
US11046670, Compound 42
Type:
Small organic molecule
Emp. Form.:
C26H24F3N
Mol. Mass.:
407.4707
SMILES:
FC(F)(F)c1ccc(cc1)-c1ccc2[C@H]3C[C@@H](N(CCc4ccccc4)CC3)c2c1 |r,TLB:29:28:27.17.26:15,18:17:13.28:15,THB:12:13:27.17.26:15|
Structure:
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