Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM50232735
Substrate
n/a
Ki
27±n/a nM
Citation
 Martin, SF; Sahn, JJ; Hodges, TR Piperazinyl norbenzomorphan compounds and methods for using the same US Patent  US11046670 Publication Date 6/29/2021 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
MAC30 | Meningioma-associated protein 30 | S2R | SGMR2_HUMAN | Sigma-2 receptor | Sigma2 receptor | TMEM97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20857.20
Organism:
Homo sapiens (Human)
Description:
Q5BJF2
Residue:
176
Sequence:
MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK
  
Inhibitor
Name:
BDBM50232735
Synonyms:
CHEMBL4069441 | US11046670, Compound 34
Type:
Small organic molecule
Emp. Form.:
C22H25Cl2N3O2S
Mol. Mass.:
466.424
SMILES:
[H][C@]12C[C@@]([H])(N(CC1)S(=O)(=O)c1cc(Cl)cc(Cl)c1)c1cc(ccc21)N1CCN(C)CC1 |r,TLB:8:5:2:24.19,20:19:2:5.6.7,THB:23:24:2:5.6.7|
Structure:
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