Reaction Details
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Sigma non-opioid intracellular receptor 1
Ligand
BDBM507041
Substrate
n/a
Meas. Tech.
Receptor Binding Assays
Ki
62±n/a nM
Citation
Martin, SF; Sahn, JJ; Hodges, TR Piperazinyl norbenzomorphan compounds and methods for using the same US Patent US11046670 Publication Date 6/29/2021 More Info.:
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
Inhibitor
Name:
BDBM507041
Synonyms:
US11046670, Compound 30
Type:
Small organic molecule
Emp. Form.:
C28H35N3O2
Mol. Mass.:
445.5964
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-c1ccc2-[#6@H]-3-[#6]-[#6@@H](-[#7](-[#6]-[#6]-3)-[#6](=O)-[#8]-[#6]-c3ccccc3)-c2c1 |r,TLB:21:18:14.31:16,32:31:20.18.19:16,THB:13:14:20.18.19:16|
Structure:
