Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM507173
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding
EC50
6.10±n/a nM
Citation
Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Horne, DB; Houze, J; Kaller, MR; Kayser, F; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yang, K; Yeh, W Heteroaryl-substituted triazoles as APJ receptor agonists US Patent US11046680 Publication Date 6/29/2021
More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM507173
Synonyms:
US11046680, Example 44.0
Type:
Small organic molecule
Emp. Form.:
C21H23FN8O4S
Mol. Mass.:
502.522
SMILES:
COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)nnc1-c1cnn(C)c1 |r,wD:16.17,(1.78,-3.65,;.6,-4.66,;-.87,-4.17,;-1.2,-2.67,;-2.62,-2.23,;-3.77,-3.21,;-3.47,-4.72,;-4.62,-5.78,;-6.1,-5.32,;-2.02,-5.24,;-1.61,-7.18,;-.19,-7.81,;1.12,-7.04,;2.46,-7.81,;3.8,-8.6,;1.7,-9.15,;3.26,-6.47,;2.66,-5.43,;4.76,-6.47,;5.53,-5.13,;7.09,-5.13,;7.85,-3.82,;7.09,-2.48,;7.85,-1.13,;5.56,-2.48,;4.76,-3.79,;-.35,-9.34,;-1.86,-9.67,;-2.65,-8.33,;-4.18,-8.14,;-4.92,-6.85,;-6.45,-7.15,;-6.62,-8.68,;-7.9,-9.5,;-5.19,-9.31,)|