Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM507171
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding
EC50
150±n/a nM
Citation
Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Horne, DB; Houze, J; Kaller, MR; Kayser, F; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yang, K; Yeh, W Heteroaryl-substituted triazoles as APJ receptor agonists US Patent US11046680 Publication Date 6/29/2021
More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM507171
Synonyms:
US11046680, Example 42.0 | US11046680, Example 47.0 | US11046680, Example 48.0
Type:
Small organic molecule
Emp. Form.:
C21H21FN8O4S
Mol. Mass.:
500.506
SMILES:
COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)nnc1-c1cncnc1 |r,wD:16.17,(1.39,-4.01,;.24,-5.07,;-1.25,-4.58,;-1.55,-3.1,;-3.03,-2.64,;-4.12,-3.64,;-3.85,-5.16,;-5,-6.19,;-6.43,-5.7,;-2.37,-5.61,;-1.94,-7.58,;-.55,-8.19,;.79,-7.43,;2.12,-8.22,;3.45,-9.01,;1.36,-9.55,;2.91,-6.89,;2.3,-5.86,;4.45,-6.89,;5.21,-5.55,;4.42,-4.22,;5.21,-2.88,;6.76,-2.88,;7.55,-1.55,;7.52,-4.22,;6.76,-5.55,;-.7,-9.74,;-2.22,-10.07,;-3,-8.74,;-4.52,-8.55,;-5.43,-9.83,;-6.97,-9.65,;-7.58,-8.31,;-6.7,-7.01,;-5.13,-7.19,)|