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Target
Adenosine receptor A2a
Ligand
BDBM508691
Substrate
n/a
Meas. Tech.
competition binding assay
Ki
1.40±n/a nM
Citation
 Amjad, A; Gallo, GV; Henderson, TJ; Kuang, R; Lim, Y; Lo, MM; Metzger, E; de Lera Ruiz, M; Stamford, A; Tempest, P; Whitehead, B; Wu, H 2,2-difluorodioxolo A2A receptor antagonists US Patent  US11046714 Publication Date 6/29/2021 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM508691
Synonyms:
8-({(cyclopropylmethyl)[(4-methyl-1,3- thiazol-2-yl)methyl]amino}methyl)- 2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4] triazolo[1,5-c]quinazolin-5-amine | US11046714, Example 127
Type:
Small organic molecule
Emp. Form.:
C20H19F2N7O2S
Mol. Mass.:
459.472
SMILES:
Cc1csc(CN(CC2CC2)Cc2nc3c4ccc5OC(F)(F)Oc5c4nc(N)n3n2)n1
Structure:
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