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Target
Kinesin-like protein KIF11
Ligand
BDBM509110
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
1.26±n/a nM
Citation
 Lerchen, H; Rebstock, A; Cancho Grande, Y; Wittrock, S; Berndt, S; Gritzan, U; Fitting, J; Stelte-Ludwig, B; Jones, P; Mahlert, C; Votsmeier, C; Schönfeld, D; Trautwein, M; Weber, E; Pawlowski, N; Greven, S; Glück, JM; Hammer, S; Dietz, L; Märsch, S Antibody drug conjugates of kinesin spindel protein (KSP) inhibitors with antiB7H3-antibodies US Patent  US11071788 Publication Date 7/27/2021 
Target
Name:
Kinesin-like protein KIF11
Synonyms:
EG5 | KIF11 | KIF11_HUMAN | KNSL1 | Kinesin Spindle Protein Eg5 | Kinesin-like protein 1 | TRIP5 | kinesin spindle protein
Type:
PROTEIN
Mol. Mass.:
119138.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1457426
Residue:
1056
Sequence:
MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIVELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEYITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNSLFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHVSQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKTSLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFSQELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNEREQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNETIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLMMLNCSENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGKDKENRGINTLERSKVEETTEHLVTKSRLPLRAQINL
  
Inhibitor
Name:
BDBM509110
Synonyms:
N-{(2S)-2-Amino-4-[{(1R)-1-[1-benzyl-4-(2,5-difluorophenyl)-1H-pyrrol-2-yl]-2,2-dimethyl propyl}(glycoloyl)amino]butanoyl}-beta-alanyl-L-glutamic acid-trifluoroacetic acid (1.1) | US11071788, Example M23
Type:
Small organic molecule
Emp. Form.:
C36H45F2N5O8
Mol. Mass.:
713.768
SMILES:
CC(C)(C)[C@@H](N(CC[C@H](N)C(=O)NCCC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(=O)CO)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
Structure:
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