Reaction Details Report a problem with these data
Target
Receptor-interacting serine/threonine-protein kinase 1 [2-375]
Ligand
BDBM509398
Substrate
n/a
Meas. Tech.
Biochemical Assay
Ki
<5.00±n/a nM
Citation
 Patel, S; Hamilton, G; Stivala, C; Chen, H; Daniels, B Bicyclic sulfones and sulfoxides and methods of use thereof US Patent  US11072617 Publication Date 7/27/2021 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 1 [2-375]
Synonyms:
RIP | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting serine/threonine-protein kinase (RIPK1)(2-375)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42278.41
Organism:
Homo sapiens (Human)
Description:
Q13546[2-375]
Residue:
374
Sequence:
QPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQ
  
Inhibitor
Name:
BDBM509398
Synonyms:
US11072617, Example 120M28
Type:
Small organic molecule
Emp. Form.:
C14H11ClF3N3O2S
Mol. Mass.:
377.769
SMILES:
F[C@H]1C[C@@H](c2ccccc2Cl)n2nc(nc12)S(=O)(=O)[C@H]1CC1(F)F |r|
Structure:
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