Reaction Details Report a problem with these data
Target
Receptor-interacting serine/threonine-protein kinase 1 [2-375]
Ligand
BDBM509468
Substrate
n/a
Meas. Tech.
Biochemical Assay
Ki
4.00±n/a nM
Citation
 Patel, S; Hamilton, G; Stivala, C; Chen, H; Daniels, B Bicyclic sulfones and sulfoxides and methods of use thereof US Patent  US11072617 Publication Date 7/27/2021 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 1 [2-375]
Synonyms:
RIP | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting serine/threonine-protein kinase (RIPK1)(2-375)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42278.41
Organism:
Homo sapiens (Human)
Description:
Q13546[2-375]
Residue:
374
Sequence:
QPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQ
  
Inhibitor
Name:
BDBM509468
Synonyms:
US11072617, Example 183M40/sup>
Type:
Small organic molecule
Emp. Form.:
C13H11F4N3OS
Mol. Mass.:
333.305
SMILES:
F[C@H]1C[C@@H](c2ccccc2)n2nc(nc12)[S@@](=O)CC(F)(F)F |r|
Structure:
Search PDB for entries with ligand similarity: