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Target
Pantetheinase [22-493]
Ligand
BDBM510532
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
0.400±n/a nM
Citation
 Fleck, MT; Godbout, C; Koolman, HF Heteroaromatic compounds as Vanin inhibitors US Patent  US11078182 Publication Date 8/3/2021 
Target
Name:
Pantetheinase [22-493]
Synonyms:
Pantetheinase (VNN1)(22-493) | VNN1 | VNN1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52490.93
Organism:
Homo sapiens (Human)
Description:
aa 22-493
Residue:
472
Sequence:
QDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDILEGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPVQERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQNLFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMNVLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLLLSQLDSHPSHSAVVNWTSYASSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKDLCCHLSYKMSENIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETASTRFEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLYEKDWASNASSGLT
  
Inhibitor
Name:
BDBM510532
Synonyms:
US11078182, Ex. 2.2
Type:
Small organic molecule
Emp. Form.:
C19H30N4O2
Mol. Mass.:
346.4671
SMILES:
CC(C)C(C)(C)Nc1ccc(cn1)C(=O)N1CC[C@@H](C1)N(C)C(C)=O |r|
Structure:
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